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Inherited disorders of DNA repair pathways arise from mutations in genes responsible for detecting and repairing DNA damage, leading to genomic instability, cancer susceptibility, and other cellular defects. One major category is Xeroderma Pigmentosum (XP), caused by defects in nucleotide excision repair (NER) genes such as XPA, XPB, or XPC. Individuals with XP are highly sensitive to ultraviolet (UV) radiation and have an increased risk of skin cancers _______ _______ ___ _________ ____ ________ ____ _____ ______.
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