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Potassium-sparing diuretics are a group of drugs that act mainly on the distal convoluted tubule and collecting duct of the nephron to prevent potassium loss during urine formation. Chemically, these drugs include aldosterone antagonists such as spironolactone and eplerenone, as well as sodium channel blockers like amiloride and triamterene. Spironolactone is a steroidal compound that competes with aldosterone for receptor binding, reducing sodium __________ ___ ___ _________ ______ ______ _______ ____ ______ ___ ______.
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