Word Count : 242

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Entamoeba histolytica attaches to the mucosa and submucosa of the colon and caecum through a series of well-defined cellular and molecular mechanisms that enable colonization and tissue invasion. After ingestion of mature cysts and excystation in the intestine, the trophozoites migrate to the large intestine, where attachment to the colonic epithelium is a critical initial step in pathogenesis. The primary ______ _______ ____ _________ ________ ____ _________.
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