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Gell and Coombs classified hypersensitivity reactions into four distinct types based on the underlying immune mechanism and the involvement of antibodies or T cells. Type I hypersensitivity, also known as immediate or IgE-mediated hypersensitivity, occurs when exposure to an allergen triggers the production of IgE antibodies. These antibodies bind to Fc receptors on mast cells and basophils, leading to ____ _____ ____ ______ _________ ___ _________ _____.
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