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Addison's disease is a rare endocrine disorder characterized by the insufficient production of steroid hormones, primarily cortisol and aldosterone, by the adrenal cortex. Biochemically, the disease involves a disruption in the hypothalamic-pituitary-adrenal (HPA) axis. Normally, corticotropin-releasing hormone (CRH) from the hypothalamus stimulates adrenocorticotropic hormone (ACTH) release from the anterior pituitary, which in __________ _________ ___ _____ _____ ___.
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