What role does Wolbachia play in the inflammatory reaction in filariasis? List the cytokines and immunoglobulins produced in human beings as an immanity response to filariasis.

Wolbachia, an endosymbiotic bacterium found in many filarial nematodes, plays a crucial role in the inflammatory reaction in filariasis. These bacteria reside within the filarial worms and significantly influence the host’s immune response. When filarial worms die, Wolbachia is released into the host’s bloodstream, triggering a strong inflammatory response. This inflammation is primarily driven by the bacterial surface proteins and endotoxins, which stimulate innate immune receptors such as Toll-like receptors (TLRs), particularly TLR2 and TLR4. Activation of these receptors leads to the production of pro-inflammatory cytokines and other immune mediators, _________ ______ ______ ________ ___ __________ _________ ___ __________.
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