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Osteoporosis is a metabolic bone disorder characterized by reduced bone mass and deterioration of bone tissue, leading to increased fragility and susceptibility to fractures. Hormones play a central role in maintaining bone homeostasis, and their imbalance is a major contributing factor in osteoporosis. Estrogen, a steroid hormone primarily produced by the ovaries, is crucial for inhibiting bone resorption ______ ______ ___ __________ __________ ______ ______ ______ ________ ___ _____ ____.
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