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De novo synthesis of purine ribonucleotides is the metabolic pathway by which cells synthesize purine nucleotides from simple, low-molecular-weight precursors rather than recycling preformed purine bases. This pathway is essential in tissues with high rates of cell division and nucleic acid synthesis, such as bone marrow and intestinal epithelium. The process occurs mainly in the cytosol and results in the formation of inosine monophosphate (IMP), which serves as the common precursor for adenine and guanine nucleotides. The purine ring is assembled stepwise on a ribose sugar backbone derived from ribose-5-phosphate, an intermediate of the pentose phosphate pathway. The first committed step is the activation of ribose-5-phosphate by ATP to _____ ____ ______ ____ _____.
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