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The classical pathway of complement activation is one of the key mechanisms by which the immune system eliminates pathogens and facilitates immune defense. It is primarily triggered by the formation of antigen-antibody complexes, particularly involving IgG or IgM antibodies. The pathway functions as a cascade of sequentially activated complement proteins, leading to opsonization, inflammation, and cell lysis. The initiation of the classical pathway begins when the complement component C1 recognizes and binds to the Fc region of antibodies that are complexed _____ ________ ____ __________ _______ ___.
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