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Chimeric antibodies are a type of engineered monoclonal antibody developed by combining genetic material from different species to enhance their therapeutic potential. In the context of animal and plant tissue culture, these antibodies are produced using recombinant DNA technology and hybridoma techniques, which often begin with animal cell cultures. Typically, the variable region of a mouse antibody, responsible for antigen recognition, is fused with the constant ____ __________ ________ __________ ___ _________ ___ _________.
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