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Mechanism based inhibitors, also known as suicide inhibitors, are a special class of enzyme inhibitors that irreversibly inactivate enzymes through a catalytic mechanism. These inhibitors resemble the natural substrate of the enzyme and bind to the active site, where the enzyme’s own catalytic activity converts the inhibitor into a highly reactive intermediate. This reactive species then forms a covalent bond with the enzyme, leading to permanent inactivation. Unlike reversible inhibitors, mechanism based inhibitors rely on the normal enzymatic process _______ __________ _____ ________ _______.
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