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Calcium ion (Ca²⁺) is essential for the process of blood coagulation. In bioinorganic chemistry, calcium acts as a cofactor for several clotting factors, including factors II (prothrombin), VII, IX, and X, by binding to γ-carboxyglutamate residues in these proteins. This binding facilitates the proper orientation of the clotting factors ______ __________ ________ _________ ______ _____ ________.
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