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The kidney is particularly susceptible to nephrotoxicity due to its unique anatomy and physiology. The high blood flow through the kidneys, approximately 25% of the cardiac output, increases the exposure of renal tissues to toxic substances. Furthermore, the kidneys are involved in the filtration and excretion of ____ _______ ___ _______ ________ __________ ____ _________ ___ ______ __________ _________.
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