What is Wobble hypothesis? Write its significance.

The Wobble hypothesis, proposed by Francis Crick in 1966, explains the flexibility in base pairing between the third base of a codon (on mRNA) and the first base of the anticodon (on tRNA) during translation. According to this hypothesis, the pairing between these two bases is not as strict as with the other bases in the codon-anticodon interaction. Specifically, Crick ________ ___ ______ _________ _______ _____.
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