Word Count : 242

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Metal ions play a crucial role in protein-RNA interactions by stabilizing the structure of RNA, facilitating folding, and mediating specific recognition between protein and RNA. RNA molecules are highly negatively charged due to the phosphate backbone, and this charge density often leads to electrostatic repulsion. Metal ions such as Mg²⁺, Mn²⁺, Zn²⁺, and sometimes monovalent cations like K⁺ help to ____ ____ _________ __________ _______ ___ ________ ______ ______ _________.
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