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Biotransformation of drugs refers to the chemical alteration of drugs in the body, mainly carried out by liver enzymes, to convert lipid-soluble drugs into water-soluble metabolites for excretion. Several factors affect the rate and extent of biotransformation. Age is an important factor. In newborns, enzyme systems are not fully developed, so drug metabolism is __________ ____ ________ ____ ______ ___ __________ _____ ____ _____.
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