What is mediated permeability and how is it different from simple diffusion?

Mediated permeability, also known as facilitated diffusion, is a process by which certain substances move across a biological membrane with the assistance of specific proteins. These proteins, called carrier proteins or channel proteins, facilitate the transport of molecules that would otherwise face barriers due ________ _________ _____ __________ ________ __________ ________ ____ ______ _____ ________ _______.
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