What are the issues raised by patenting of onco-mouse?

The OncoMouse is a genetically engineered mouse that has been designed to develop tumors as part of its natural lifespan. It was developed by researchers at Harvard University in the early 1980s, and it became the first animal to be patented in the United States in 1988. The patent on the OncoMouse raised a number of issues related to the patentability of living organisms, the ethical implications of animal research, and the economic and legal implications of patenting a research tool.

One of the primary issues raised by the patenting of the OncoMouse is the question of whether living organisms should be patentable. Prior to the OncoMouse, _______ ____ ________ _______ _______ _______ ____ ______ __________.
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