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Suppositories are solid dosage forms intended for insertion into body orifices such as the rectum, vagina, or urethra, where they melt, soften, or dissolve at body temperature to exert local or systemic effects. They are particularly useful when the oral route is unsuitable, such as in cases of vomiting, unconsciousness, difficulty in swallowing, or when drugs are extensively metabolized in the liver. Rectal suppositories are the most common type and are typically torpedo-shaped for ease of insertion, while vaginal suppositories, also known as pessaries, are usually globular or oviform, and urethral suppositories are slender and pencil-shaped. The formulation of suppositories involves incorporation of the active pharmaceutical ingredient into a suitable base. The ______ _________ ____ ___ _________ _______ ________.
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