Role of calcium in regulation of muscle contraction

Calcium plays a crucial role in regulating muscle contraction by acting as a key signaling molecule in excitation-contraction coupling. When a nerve impulse reaches the neuromuscular junction, it triggers the release of acetylcholine, leading to depolarization of the muscle fiber membrane. This depolarization spreads through the ___ ______ _______ ___ _____ _________ __________ _________ ___ ______ _____.
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