Name the key regulatory enzyme of de novo cholesterol biosynthesis. How does it exert the regulation?

The key regulatory enzyme in the de novo cholesterol biosynthesis pathway is HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase). This enzyme is crucial in the synthesis of cholesterol, as it catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the cholesterol biosynthetic pathway.

Regulation of HMG-CoA Reductase occurs through several mechanisms:

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