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Lysosomal proteolysis is a fundamental process in cellular metabolism and turnover, involving the degradation of proteins and other macromolecules within lysosomes. Lysosomes are membrane-bound organelles that contain a variety of hydrolytic enzymes, including proteases, nucleases, lipases, and glycosidases, which function optimally at acidic pH. Proteolysis within lysosomes primarily occurs through the action of proteases called cathepsins, which _______ _______ _______ ________ _____ _____ __________ ________ _______ _________ _____ _________.
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