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The intrinsic pathway of apoptosis, also known as the mitochondrial pathway, is a crucial mechanism by which cells undergo programmed cell death in response to internal stress signals such as DNA damage, oxidative stress, or growth factor deprivation. This pathway is tightly regulated by the Bcl-2 family of proteins, which includes both pro-apoptotic members (Bax, Bak, Bid) and anti-apoptotic members (Bcl-2, Bcl-xL). Under __________ ___ ________ ________ ____.
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