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Signal transduction through G-protein coupled receptors (GPCRs) is a fundamental mechanism by which cells respond to extracellular signals. The process begins when an extracellular ligand, such as a hormone, neurotransmitter, or sensory molecule, binds to the GPCR located on the plasma membrane. This binding induces a conformational change in the receptor, which allows it to interact with a __________ ________ ____ _______ _________ ______ ____ ____ ____ ___ ________ __________.
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