Explain the various sources of teratogens and their effects. Describe the process of teratogenesis and the mechanism of action.
A teratogen is something that can cause birth defects or abnormalities in a developing embryo or fetus upon exposure. Teratogens include some medications, recreational drugs, tobacco products, chemicals, alcohol, certain infections, and in some cases, health problems such as uncontrolled diabetes in pregnant people. Exposure to a teratogen can occur through ingestion or environmental exposure during pregnancy.
Teratogens can begin affecting the developing embryo as early as 10 to 14 days after conception. During embryonic development, there are periods when the developing organ systems show more sensitivity to teratogens. Specifically, if exposure to a teratogen occurs during the first 3.5 to 4.5 weeks of gestation, a neural tube defect, such as spina bifida or anencephaly, may result.
Teratogens may affect the embryo or fetus in a number of ways, causing physical malformations, problems in the behavioral or emotional development of the child, and decreased intellectual quotient (IQ) in the child. Additionally, teratogens may also affect pregnancies and cause complications such as preterm labors, spontaneous abortions, or miscarriages. Teratogens are classified into four types: physical agents, metabolic conditions, infection, and finally, drugs and chemicals.
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