Explain the metabolism of HDL with the help of a diagram.

 HDL metabolism begins in the liver and in the intestine. Lipid-free apolipoprotein A-I (apoA-I), which is produced and secreted by the above tissues, interacts physically and extracellularly with the membrane lipid transporter ATP Binding Cassette Transporter A 1 (ABCA 1) and this interac tion promotes the transfer of phospholipids and cholesterol to apoA-I thus forming lipid-poor apoA-I [1]. These lipid- poor apoA-I particles acquire additional phospholipids and cholesterol from peripheral cells such as the macrophages of the arterial wall via interaction with ABCA1 and are con verted first to discoidal pre- _{_______ ___ _______ _______ __________ _________ ___ _____ _______ ______.
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