Briefly explain the general mechanism of signal generation.

 Even though action of every hormone is mediated through the generation of a signal, there are great differences in the kind of signal generated and the manner ¡n which it occurs. The difference ¡s determined by the nature of the hormones involved i.e. group I hormones or the group 11 hormones. Let us get to know more about this aspect next.

Group I Hormones

The ligand-receptor complex is the signal for group I hormones. These hormones which are lipophilic, easily diffuse through the plasma membrane of all cells and encounter their specific, high-affinity intracellular receptors in target cells. As already mentioned, these receptors can be located in the cytoplasm or in the nucleus of target cells. The hormone-receptor complex undergoes, first, an activation reaction. This can occur by the following two mechanisms _____ _________ ___ ________ ________ ___ ___ ________ ___ ____.
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