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Aconitase is a key enzyme in the tricarboxylic acid (TCA) cycle, catalyzing the reversible isomerization of citrate to isocitrate via cis-aconitate. Structurally, aconitase contains a \[4Fe-4S] iron-sulfur cluster, which plays a critical role in substrate binding and catalysis rather than electron transfer. The mechanism begins with citrate binding to the active site, where one of the hydroxyl groups of citrate _________ _____ _____ _____ ______ ____ _____ ______.
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