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Phosphodiester bond formation is the fundamental chemical reaction that links nucleotides together to form DNA and RNA polymers. Each nucleotide consists of a nitrogenous base, a pentose sugar, and a phosphate group. The phosphodiester bond specifically connects the 3′ hydroxyl (–OH) group of the sugar of one nucleotide to the 5′ _____ _____ _______ _____ _________ ___ __________ __________ __________.
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