Elucidate drug use and dependence disorder. 

Drug use and dependence disorder, also known as substance use disorder (SUD), is a condition characterized by a compulsive pattern of drug use, despite the harmful consequences that may arise from its use. This disorder affects the brain's reward system, leading to an intense desire to continue using the substance, and an inability to control or stop its use. SUD can occur with the use of various substances, including alcohol, _________ _____ _______ ________ _______ ______.
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