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In molecular cell biology, the synthesis, sorting, processing, and modification of proteins are essential for cellular function and are carried out by a coordinated network of organelles. Proteins are synthesized on ribosomes, either free in the cytosol or bound to the rough endoplasmic reticulum (RER). Ribosomes on the RER produce proteins destined for secretion, incorporation into membranes, or delivery to specific organelles. Once synthesized, these nascent proteins enter the _____ ________ _______ ___ _____ _____ __________.
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