Discuss the upstream and internal promotes of eukaryotic transcription.

In eukaryotic transcription, the process of gene expression begins with the initiation of transcription at specific genomic regions. The regulation of this initiation is largely controlled by two key elements: upstream and internal promoters.

Upstream Promoters are located before the transcriptional start site, usually at a distance ranging from ______ _____ __________ _____ ________ ______.
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