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B-cells, also known as B lymphocytes, are a critical component of the adaptive immune system. Their development begins in the bone marrow, where progenitor B-cells undergo a series of genetic rearrangements to form a unique B-cell receptor (BCR). The activation of B-cells occurs when the BCR recognizes and binds to a specific antigen. This binding triggers receptor-mediated signaling pathways involving kinases such as Lyn, Syk, ____ ___ ______ _________ _____ ______ _________ ______ __________ ______ ____ __________.
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