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The classical pathway of the complement system is one of the major mechanisms of innate immunity that helps in the clearance of pathogens and immune complexes. It is initiated primarily by the binding of the complement protein C1 to antigen-antibody complexes, usually involving IgG or IgM antibodies. The C1 complex is composed of three subcomponents: C1q, C1r, and C1s. C1q binds to the _____ _______ ____ _____ ___ ___ ____ ______ ____ ___ ______.
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