Describe transcription bubble formation in prokaryotes.
In prokaryotes, transcription begins with the formation of the transcription bubble, which is a region of locally unwound DNA that allows the RNA polymerase enzyme to synthesize RNA. The process starts when the RNA polymerase enzyme binds to a specific region on the DNA known as the promoter. The promoter is located upstream of the gene to ______ _____ ________ _____ ___ _________ ________.
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