Describe the structure and processes of assembly and disassembly microtubules.

Microtubules are dynamic, cylindrical structures made up of α-tubulin and β-tubulin heterodimers. These heterodimers polymerize head-to-tail to form protofilaments, which align laterally to create a hollow tube with a diameter of about 25 nm. Typically, 13 protofilaments associate to form a microtubule.

The assembly of microtubules begins with nucleation, where a small number of tubulin dimers aggregate to form an _____ ______ _______ ____ _____ _______ ____ _______ __________ ______.
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