Word Count : 235

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Ubiquitin and proteasome play a central role in maintaining cellular protein quality control by selectively degrading misfolded or damaged proteins, which is crucial in preventing non-infectious human diseases such as neurodegenerative disorders. Ubiquitin is a small, highly conserved protein that functions as a molecular tag. Misfolded proteins are first recognized by cellular chaperones and quality control systems. Once ___ __________ ___ _______ ______ ___ ______ ________ ___.
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