Word Count : 344

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Fatty acid metabolism begins with the activation of fatty acids before their entry into the oxidative pathway. In the cytosol, or more precisely on the outer mitochondrial membrane, fatty acids are activated by the enzyme fatty acyl-CoA synthetase, also known as thiokinase. This reaction requires ATP and Coenzyme A (CoA), converting a free fatty acid into a _______ ____ ___ ______ ________ _____ _____ _________.
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