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The Michaelis-Menten equation describes the rate of enzymatic reactions by relating reaction rate to substrate concentration. The derivation starts with the basic enzyme-catalyzed reaction: [ E + S \xrightleftharpoons[k_{-1}]{k_1} ES \xrightarrow{k_2} E + P ] where (E) is the enzyme, (S) is the substrate, (ES) is the enzyme-substrate complex, and (P) is the product. (k_1) and (k_{-1}) are the rate constants for ____ _____ ___ ________ _____ ____ ______.
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