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DNA replication in prokaryotes and eukaryotes follows the semi-conservative principle but differs significantly in complexity, organization, and regulation. Prokaryotic DNA replication occurs in organisms such as bacteria, which typically possess a single, circular chromosome. Replication begins at a single origin of replication called oriC and proceeds bidirectionally. The process is rapid and efficient, coordinated with the cell cycle, and usually completed before cell ______ _________ _______ ____ ________ ______ ___ ________ __________ ____.
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