What is the metabolic significance of HMP Pathway?

We have seen that CO2 is the characteristic product in the HMP pathway, which is not produced in the Embden-Meyerhof pathway. CO2 produced in this pathway is used for the synthesis of fatty acids and purine bases.

The reduced form of NADP (NADPH) is utilized for the synthesis of fatty acids, cholesterol, steroids and also in thé synthesis of amino acids via glutamate dehydrogenase outside the mitochondria. In fact tissues specializing in active lipogenesis — liver, adipose tissue and the lactating mammary glands — also posses an active I-IMP pathway.

The pentose sugars produced in HMP shunt are utilized for the synthesis of nucleic acids and nucleoticles.

Skeletàl muscle has low activity of glucose-6-phosphate dehydogenase. Yet, like most other tissues it can synthesize ribose-5-phosphate. This is probably accomplished by a reversai of the shunt pathway ____ __________ _________ ________ ___ ___ _____ ______ ____ ________ ____ ___.
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