Anatomical and Physiological barrier of Innate Immunity

The innate immune system provides the first line of defense against pathogens, relying on both anatomical and physiological barriers to prevent infection. Anatomical barriers include physical structures like the skin and mucous membranes. The skin acts as a tough outer layer, preventing pathogens from entering the ____ ______ _______ ___ __________ ______ ________ _____ ____ ______ _________.
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