Describe mechanism of B-cell tolerance

B-cell tolerance is a crucial mechanism in immunology that ensures B-cells do not react against the body's own tissues, preventing autoimmune diseases. It involves several stages of development, primarily occurring in the bone marrow and peripheral lymphoid tissues.

In the central tolerance phase, immature B-cells undergo a process called negative selection. When a B-cell receptor (BCR) recognizes _________ _________ __________ ___ ______ ________ _________.
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