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The ABO blood group system is one of the most important and well-studied human blood group systems, discovered by Karl Landsteiner in 1901. It is determined by the presence or absence of specific antigens on the surface of red blood cells, which are glycoproteins and glycolipids known as A and B antigens. The ABO system is controlled by a single gene, the ABO gene, located on chromosome 9, which ______ __________ _________ ________ _____ _______.
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