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Pregabalin is synthesized through a sequence of reactions designed to achieve high selectivity, minimal waste, and safer reaction conditions in alignment with green chemistry principles. A commonly adopted route begins with the preparation of a substituted nitrile or ester precursor derived from readily available petrochemical feedstocks, emphasizing atom economy and efficient functional group transformations. The initial step generally involves the formation of a chiral intermediate _________ ______ ________ _________ ________ ______ __________ ________ ___ _________ _________ ______.
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