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Herbal-drug interaction refers to the alteration in the pharmacological activity of a conventional drug when it is taken simultaneously with herbal medicines. These interactions occur because active phytoconstituents present in herbs can influence the absorption, metabolism, distribution, or excretion of synthetic drugs, thereby affecting their therapeutic effectiveness or increasing the risk of adverse effects. Such interactions may arise due to the modulation of drug-metabolizing enzymes, especially cytochrome P450 isoenzymes, or through changes in drug transporters and plasma protein binding. As herbal medicines are widely used due to their natural origin, patients often take them along with prescribed drugs, sometimes without informing healthcare providers. This creates a significant ______ __________ ________ _____ _______ ______.
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