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The immune system is composed of diverse cells that arise primarily from hematopoietic stem cells in the bone marrow and function together to defend the body against pathogens while maintaining self-tolerance. These cells are broadly classified into innate and adaptive immune cells based on their mechanisms of recognition and response. Cells of the innate immune system provide immediate, non-specific defense. Neutrophils are the most abundant circulating leukocytes and act as first responders by phagocytosing microbes and releasing antimicrobial enzymes and reactive oxygen species. Eosinophils participate mainly in defense against parasitic infections and contribute to allergic reactions through the release of cytotoxic _____ ____ ___ ________ ___ _________ ____ ___.
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