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Muscle fatigue during prolonged physical activity arises from a complex interplay of biochemical processes that impair the muscle’s ability to sustain contraction. Initially, muscle contraction depends on the availability of adenosine triphosphate (ATP), which provides the immediate energy for cross-bridge cycling. During intense or sustained activity, ATP consumption exceeds its rate of regeneration, leading to a transient energy deficit. As _______ _______ _____ _________ ___ ___ _________ ____ ____ ____.
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