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Ethical guidelines in animal research are essential to ensure the humane treatment of animals while maintaining the integrity and reliability of scientific outcomes. The use of animals in research raises moral, legal, and scientific concerns, which necessitate a structured framework of ethical principles. These guidelines are designed to minimize harm, reduce suffering, and justify the use of animals only when no viable alternatives exist. One of the foundational principles in animal research ethics is the concept of the _________ ___ ________ ________ ___ _________.
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