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Somatoform disorders, now often referred to as somatic symptom and related disorders in the DSM-5, involve the presence of physical symptoms that are not fully explained by a medical condition, substance use, or another mental disorder. These disorders present a complex interplay of biological and psychological factors that contribute to their onset and maintenance. Biological factors play a significant role in the development of somatoform disorders. One of the major biological influences includes genetic predisposition. Studies indicate that somatoform disorders can run in families, suggesting that inherited traits such as heightened sensitivity to pain or a tendency toward anxiety may be involved. Neurobiological evidence points to irregularities in the brain structures and neurotransmitter systems involved in _________ ________ ______ ___ _____ ___ ______.
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